Faculty of Science, Engineering and Agriculture

Simon Mnyakeni Moleele

Associate Professor and HoD · Department of Chemistry

Academic Profile

Simon Mnyakeni Moleele

Simon Mnyakeni Moleele
Department of Chemistry

Simon Mnyakeni Moleele

Associate Professor and HoD

Highest qualificationPhD Chemistry (Wits University)
SpecialisationOrganic synthesis and medicinal chemistry
Research

Research Interests

Synthesis and In silico studies of antituberculosis and antidiabetic drugs containing 5 membered rings such as thiazolidinediones, oxazolidinediones, rhodanines, hydantoins and thiohydantoins

Current Work

Current & Recent Projects

  • Synthesis of oxazolidinediones as potential antidiabetic drugs
  • Synthesis of quinazoline containing anti-TB drugs with 1,3,5-triazine as a linker
  • Hybridization of anti-TB and anti-AIDS drugs
Teaching

Teaching Areas

  • Lectures on organic chemistry at 2nd year level and spectroscopy, mainly NMR spectroscopy, at 3rd and 4th year levels.
Research Profiles

Professional Profiles

Professional

Membership & Supervision

  • SACI member membership number 16676
Scholarship

Recent Articles

  1. “Synthesis of new benzenesulfonylthiourea-containing compounds”, Bongani S Tshifaro, Mpelegeng V. Bvumbi, Tiyisela N Mbhokazi, and Simon S. Mnyakeni Moleele, Arkivoc 2025 (3) 202612539. doi.org/10.24820/ark.5550190.p012.539
  2. “Synthesis and Characterization of New 5-Benzylidene thioimidazolone Esters”, Unarine Tshishonga, Mpelegeng V Bvumbi and Simon S Mnyakeni Moleele, J Org Chem Chem Sci, 2026, 4: 1-13
  3. Preparation of 1-phenylmenthol from menthone as a template for molecularly imprinting and its subsequent adsorption”, Masala Mugeri, Simon Mnyakeni-Moleele, Nikita Tawanda Tavengwa, Results in Chemistry, 2026, 25, 103253.
  4. “In Silico Study of New Sulfonylurea Analogs as Potential Antidiabetic Agents: ADMET, Molecular Docking and Dynamics, MM-GBSA and DFT Approach”, Vhushavhelo Musinyali, Kabelo P. Mokgopa, Simon S. Mnyakeni-Moleele, Tendamudzimu Tshiwawa and Ndivhuwo R. Tshiluka, Journal of Chemistry, 2026; 1 of 16 doi.org/10.1155/joch/819325.