Dr Simon Mnyakeni Moleele

Designation: Senior Lecturer (Organic Chemistry)
Qualifications: BSCHON (UNIVERSITY OF JOHANNESBURG), PHD (UNIVERSITY OF JOHANNESBURG)
Telephone: 0159628190
Email address: mnyakeni.moleele@univen.ac.za
Office: NATURAL SCIENCE BUILDING Building

Research interests:

Synthesis of antituberculosis and antimalarial drugs using triazine as a linker. Synthesis of antidiabetic drugs. Isolation of biologically active ingredients from natural products.

List of selected publications:

[1] Isaiah DI Ramaite, Musa D Maluleke, Simon S Mnyakeni Moleele “Synthesis and Evaluation of Isoflavones as Potential Anti-inflammatory inhibitors”, Arab. J. Sci. Eng. 2017, 42, 4263–4271

[2] Chigayo K, Mojapelo PEL, Mnyakeni Moleele SS, Misihairabgwi J Phytochemical and antioxidant properties of different solvent extracts of Kirkia wilsii tubers,” Asian Pac J. Trop Biomed, 2016. 6, 1037-1043

[3] David Gravestock, Amanda L. Rousseau, Anna C. U. Lourens, Simon S. Moleele, Robyn L. van Zyl, Paul A. Steenkamp. “Expeditious synthesis and biological evaluation of novel 2, N6-disubstituted 1,2-dihydro-1,3,5-triazine-4,6-diamines as potential antimalarials” Eur. J. Med. Chem. 2011, 46, 2022-2030

[4] Moira L. Bode, David Gravestock, Simon S. Moleele, Christiaan W. van der Westhuyzen, Stephen C. Pelly, Paul A. Steenkamp, Heinrich C. Hoppe, Tasmiyah Khan and Lindiwe A. Nkabinde, “Synthesis and biological evaluation of imidazo[1,2-a]pyridin-3-amines as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs)”, Bioorg. Med. Chem., 2011, 19, 4227-4237

[5] S S Moleele, J P Michael and C B de Koning, “Tetralones as precursors for the synthesis of 2,2’-disubstituted 1,1’-binaphthyls and related compounds”, Tetrahedron, 2008, 64, 10573-10580

Full list of publications:

https://www.scopus.com/authid/detail.uri?authorId=57191979244
https://www.scopus.com/authid/detail.uri?authorId=8583587900